The RCCX Hypothesis
Aka The RCCX Theory
Links relating to the RCCX Hypothesis / Theory from Dr. Sharon Meglathery which may explain the “Chronic Constellation” (my term) for so many major comorbidities with as yet unexplained hEDS/hypermobility.
Dr. Meglathery was initially optimistic that she could get some bench research started to help support this, but ran into several road blocks, so none is yet underway to my knowledge. But the hypothesis really resonates with many of us. (Last updated February 27, 2023)
- The RCCX Hypothesis (first posted February 2016 by Sharon Meglathery, MD)
- Joint Hypermobility: A Red Flag for Gene-Based Chronic Disease Cluster June 2017 McEvoy, M in Holistic Primary Care
- Hyper Joint Mobility, EDS, Collagen, Histamin & CIRS: Implications May 2017 McEvoy, M in Metabolic Healing
- Ehlers-Danlos Syndrome Caused by Biallelic TNXB Variants in Patients with Congenital Adrenal Hyperplasia Chen, Perritt et al 2016 via Springer
- Broadening the Spectrum of Ehlers-Danlos Syndrome in Patients with Congenital Adrenal Hyperplasia Morisette, Chen, Perritt et al 2015
- Tenascin-X, Congenital Adrenal Hyperplasia, and the CAH-X Syndrome. 2018 Miller, Merke
- High-Throughput Screening for CYP21A1P-TNXA/TNXB Chimeric Genes Responsible for Ehlers-Danlos Syndrome in Patients with Congenital Adrenal Hyperplasia 2019 Qizong Lao, Brittany Brookner, Deborah P Merke 2019
- The Prevalence of the Chimeric TNXA/TNXB Gene and Clinical Symptoms of Ehlers-Danlos Syndrome with 21-Hydroxylase Deficiency 2020 -J Clin Endocrinol Metab Yinjie Gao, Lin Lu, Bingqing Yu, Jiangfeng Mao, Xi Wang, Min Nie, Xueyan Wu